abstract：BACKGROUND:MicroRNAs have an important role in diverse biological processes including tumorigenesis. MiR-223 has been reported to be deregulated in several human cancer types. However, its biological role has not been functionally characterized in lung squamous cell carcinoma (LSCC). The following study investigates th...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Luo P,Wang Q,Ye Y,Zhang J,Lu D,Cheng L,Zhou H,Xie M,Wang B

更新日期：2019-02-12 00:00:00

abstract：BACKGROUND:Glioma is the most common intracranial neoplasm with vasculogenic mimicry formation as one form of blood supply. Many RNA-binding proteins and long non-coding RNAs are involved in tumorigenesis of glioma. METHODS:The expression of ZRANB2, SNHG20 and FOXK1 in glioma were detected by real-time PCR or western ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Li X,Xue Y,Liu X,Zheng J,Shen S,Yang C,Chen J,Li Z,Liu L,Ma J,Ma T,Liu Y

更新日期：2019-02-11 00:00:00

abstract：BACKGROUND:Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved intracellular mechanism for lysosomal degradation of damaged cellular components. The specific degradation of nuclear components by the autophagy pathway is called nucleophagy. Most studies have focused on autophagic turnover ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Li Y,Jiang X,Zhang Y,Gao Z,Liu Y,Hu J,Hu X,Li L,Shi J,Gao N

更新日期：2019-02-11 00:00:00

abstract：BACKGROUND:Pancreatic ductal adenocarcinoma is one of the leading causes of cancer-related death worldwide. Immune checkpoint blockade therapy, including anti-PD-1 and anti-PD-L1, is a new therapeutic strategy for cancer treatment but the monotherapy with PD-L1 inhibitors for pancreatic cancer is almost ineffective for...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Fan P,Zhao J,Meng Z,Wu H,Wang B,Wu H,Jin X

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Rhein is a lipophilic anthraquinone extensively found in medicinal herbs. Emerging evidence suggests that rhein has significant antitumor effects, supporting its potential use as an antitumor agent. The IL6/STAT3 signaling pathway has been suggested as an attractive target for the discovery of novel cancer t...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang L,Lin S,Kang Y,Xiang Y,Xu L,Li J,Dai X,Liang G,Huang X,Zhao C

更新日期：2019-01-23 00:00:00

abstract：:Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the specific complex named shelterin and a tight nucleosomal organizati...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Cacchione S,Biroccio A,Rizzo A

更新日期：2019-01-17 00:00:00

abstract：BACKGROUND:In this research, we aimed to resolve contradictory results whether SOX9 plays a positive or negative role in melanoma progression and determine whether SOX9 and its closely related member SOX10 share the same or distinct targets in mediating their functions in melanoma. METHODS:Immunofluorescence, TCGA dat...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang X,Liang R,Liu C,Liu JA,Cheung MPL,Liu X,Man OY,Guan XY,Lung HL,Cheung M

更新日期：2019-01-14 00:00:00

abstract：:RANKL/RANK/OPG system consists of three essential signaling molecules: i) the receptor activator of nuclear factor (NF)-kB-ligand (RANKL), ii) the receptor activator of NF-kB (RANK), and iii) the soluble decoy receptor osteoprotegerin (OPG). Although this system is critical for the regulation of osteoclast differentia...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Infante M,Fabi A,Cognetti F,Gorini S,Caprio M,Fabbri A

更新日期：2019-01-08 00:00:00

abstract：BACKGROUND:Annexin A2 is increased in serous ovarian cancer and plays an essential role in ovarian cancer invasion and metastasis. In combination with S100A10, annexin A2 plays an important role in the plasminogen activator system regulating plasmin production. The aim of this study was to investigate the potential uti...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lokman NA,Ho R,Gunasegaran K,Bonner WM,Oehler MK,Ricciardelli C

更新日期：2019-01-08 00:00:00

abstract：BACKGROUND:Triple negative breast cancer (TNBC) is an aggressive neoplasia with no effective therapy. Our laboratory has developed a unique TNBC cell model presenting epithelial mesenchymal transition (EMT) a process known to be important for tumor progression and metastasis. There is increasing evidence showing that e...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Su Y,Hopfinger NR,Nguyen TD,Pogash TJ,Santucci-Pereira J,Russo J

更新日期：2018-12-14 00:00:00

abstract：PURPOSE:There has been no satisfactory treatment for advanced melanoma until now. Targeted radionuclide therapy (TRNT) may be a promising option for this heretofore lethal disease. Our goal in this study was to synthesize 131I-N-(2-(diethylamino)ethyl)-5-(iodo-131I)picolinamide (131I-5-IPN) and evaluate its therapeutic...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Xu X,Yuan L,Gai Y,Liu Q,Yin L,Jiang Y,Wang Y,Zhang Y,Lan X

更新日期：2018-12-11 00:00:00

abstract：BACKGROUND:Interleukin-32 (IL-32) has been associated with various diseases. Previous studies have shown that IL-32 inhibited the development of several tumors. However, the role of IL-32γ, an isotype of IL-32, in skin carcinogenesis remains unknown. METHODS:We compared 7,12-Dimethylbenz[a]anthracene/12-O-Tetradecanoy...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lee YS,Lee CH,Bae JT,Nam KT,Moon DB,Hwang OK,Choi JS,Kim TH,Jun HO,Jung YS,Hwang DY,Han SB,Yoon DY,Hong JT

更新日期：2018-11-28 00:00:00

abstract：BACKGROUND:Thyroid cancer is one of the most prevalent malignancies in endocrine system. Further understanding and revealing the molecular mechanism underlying thyroid cancer are indispensable for the development of effective diagnosis and treatments. In the present study, we attempted to provide novel basis for target...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu H,Deng H,Zhao Y,Li C,Liang Y

更新日期：2018-11-21 00:00:00

abstract：BACKGROUND:Metastasis is the primary cause of death in renal cell carcinoma (RCC). Loss of cell-to-cell adhesion, including tight junctions (TJs) is the initial step in the process of metastasis. Claudin-7 (CLDN7) is a major component of TJs. However, the clinical significance and its regulation of kidney tumorigenesis...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Li Y,Gong Y,Ning X,Peng D,Liu L,He S,Gong K,Zhang C,Li X,Zhou L

更新日期：2018-11-14 00:00:00

abstract：BACKGROUND:Reprogrammed energy metabolism has become an emerging hallmark of cancer in recent years. Transporters have been reported to be amino acid sensors involved in controlling mTOR recruitment and activation, which is crucial for the growth of both normal and tumor cells. L-type amino acid transporter 2 (LAT2), e...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Feng M,Xiong G,Cao Z,Yang G,Zheng S,Qiu J,You L,Zheng L,Zhang T,Zhao Y

更新日期：2018-11-12 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) posttranscriptionally regulate gene expression and thereby contribute to the modulation of numerous complex and disease-relevant cellular processes, including cell proliferation, cell motility, apoptosis and stress response. miRNA-31-5p is encoded on a genomic fragile site, 9p21.3, which i...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Que KT,Zhou Y,You Y,Zhang Z,Zhao XP,Gong JP,Liu ZJ

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:Actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1), a long noncoding RNA, is significantly highly expressed and associated with metastasis and poor prognosis in many cancers, including nasopharyngeal carcinoma (NPC). In this study, we aim to identify the role of AFAP1-AS1 acting as an oncogenic ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lian Y,Xiong F,Yang L,Bo H,Gong Z,Wang Y,Wei F,Tang Y,Li X,Liao Q,Wang H,Zhou M,Xiang B,Wu X,Li Y,Li X,Chen X,Li G,Guo C,Zeng Z,Xiong W

更新日期：2018-10-16 00:00:00

abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) is a leading cause of death worldwide. MicroRNAs (miRNAs) have been indicated as crucial actors in cancer biology. Accumulating evidence suggests that miRNAs can be used as diagnostic and prognostic markers for NSCLC. METHODS:The purpose of this study was to characterize a...

journal_title：Journal of experimental & clinical cancer research : CR

authors： He X,Chen SY,Yang Z,Zhang J,Wang W,Liu MY,Niu Y,Wei XM,Li HM,Hu WN,Sun GG

更新日期：2018-09-18 00:00:00

abstract：BACKGROUND:Emerging evidence has shown long noncoding RNAs (lncRNAs) exert important roles in colorectal cancer (CRC) tumorigenesis. However, most lncRNAs involved in this process remain undefined and the underlying molecular mechanisms mediated by lncRNAs are largely unknown. METHODS:An unbiased screening was used to...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yu J,Han Z,Sun Z,Wang Y,Zheng M,Song C

更新日期：2018-09-10 00:00:00

abstract：BACKGROUND:Enzymatically inactive chitinase-like protein CHI3L1 drives inflammatory response and promotes tumor progression. However, its role in gastric cancer (GC) tumorigenesis and metastasis has not yet been fully elucidated. We determined the significance of CHI3L1 expression in patients with GC. We also explored ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Geng B,Pan J,Zhao T,Ji J,Zhang C,Che Y,Yang J,Shi H,Li J,Zhou H,Mu X,Xu C,Wang C,Xu Y,Liu Z,Wen H,You Q

更新日期：2018-08-30 00:00:00

abstract：BACKGROUND:Poly C Binding Protein 1 (PCBP1) is an RNA-binding protein that binds and regulates translational activity of subsets of cellular mRNAs. Depletion of PCBP1 is implicated in various carcinomas, but the underlying mechanism in tumorigenesis remains elusive. METHODS:We performed a transcriptome-wide screen to ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Shi H,Li H,Yuan R,Guan W,Zhang X,Zhang S,Zhang W,Tong F,Li L,Song Z,Wang C,Yang S,Wang H

更新日期：2018-08-07 00:00:00

abstract：BACKGROUND:Chronic myelogenous leukemia (CML) is a myeloproliferative disorder caused by expression of the chimeric BCR-ABL tyrosine kinase oncogene, resulting from the t(9;22) chromosomal translocation. Imatinib (gleevec, STI-571) is a selective inhibitor of BCR-ABL activity highly effective in the treatment of CML. H...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Monteleone F,Taverna S,Alessandro R,Fontana S

更新日期：2018-07-25 00:00:00

abstract：BACKGROUND:Aberrant expression of Wiskott-Aldrich syndrome protein interacting protein family member 1 (WIPF1) contributes to the invasion and metastasis of several malignancies. However, the role of WIPF1 in human pancreatic ductal adenocarcinoma (PDAC) remains poorly understood. METHODS:Human pancreatic cancer sampl...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Pan Y,Lu F,Xiong P,Pan M,Zhang Z,Lin X,Pan M,Huang H

更新日期：2018-07-24 00:00:00

abstract：BACKGROUND:Oxaliplatin belongs to the platinum-based drug family and has shown promise in treating cancer by binding to DNA to induce cytotoxicity. However, individual patients show diverse therapeutic responses toward oxaliplatin due to yet-unknown underlying mechanisms. We recently established that oxaliplatin also e...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Chen HY,Islam A,Yuan TM,Chen SW,Liu PF,Chueh PJ

更新日期：2018-07-20 00:00:00

abstract：BACKGROUND:Bone metastasis is a leading cause of morbidity and mortality in advanced prostate cancer (PCa). Downexpression of miR-133a-3p has been found to contribute to the progression, recurrence and distant metastasis in PCa. However, clinical significance of miR-133a-3p in bone metastasis of PCa, and the biological...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Tang Y,Pan J,Huang S,Peng X,Zou X,Luo Y,Ren D,Zhang X,Li R,He P,Wa Q

更新日期：2018-07-18 00:00:00

abstract：BACKGROUND:As novel biomarkers for various cancers, microRNAs negatively regulate genes expression via promoting mRNA degradation and suppressing mRNA translation. miR-589 has been reported to be deregulated in several human cancer types. However, its biological role has not been functionally characterized in gastric c...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang F,Li K,Pan M,Li W,Wu J,Li M,Zhao L,Wang H

更新日期：2018-07-16 00:00:00

abstract：BACKGROUND:The disruption of E-cadherin-mediated adhesion is considered an important driver of tumor progression. Nevertheless, numerous studies have demonstrated that E-cadherin promotes growth- or invasion-related signaling, contrary to the prevailing notion. During tumor progression, epithelial ovarian cancer (EOC) ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Rea K,Roggiani F,De Cecco L,Raspagliesi F,Carcangiu ML,Nair-Menon J,Bagnoli M,Bortolomai I,Mezzanzanica D,Canevari S,Kourtidis A,Anastasiadis PZ,Tomassetti A

更新日期：2018-07-11 00:00:00

abstract：BACKGROUND:Patients with endometrial cancer (EC) and presumably with good prognosis may develop a recurrence indicating that the classification of this tumor is still not definitive and that new markers are needed to identify a subgroup at risk of relapse. The cell adhesion molecule L1CAM is highly expressed in several...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Corrado G,Laquintana V,Loria R,Carosi M,de Salvo L,Sperduti I,Zampa A,Cicchillitti L,Piaggio G,Cutillo G,Falcioni R,Vizza E

更新日期：2018-07-06 00:00:00

abstract：BACKGROUND:Melanoma is a malignant tumor with high misdiagnosis rate and poor prognosis. The bio-targeted therapy is a prevailing method in the treatment of melanoma; however, the accompanying drug resistance is inevitable. SH2 superbinder, a triple-mutant of the Src Homology 2 (SH2) domain, shows potent antitumor abil...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu AD,Xu H,Gao YN,Luo DN,Li ZF,Voss C,Li SSC,Cao X

更新日期：2018-07-05 00:00:00

abstract：BACKGROUND:The signal transducer and activator of transcription (STAT) and transforming growth factor-β (TGF-β) signaling pathways play important roles in epithelial ovarian cancer (EOC). However, the mechanism of crosstalk between two pathways is not completely understood. METHODS:The expression of STAT1 protein was ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Tian X,Guan W,Zhang L,Sun W,Zhou D,Lin Q,Ren W,Nadeem L,Xu G

更新日期：2018-05-11 00:00:00

abstract：BACKGROUND:Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of tumors, with aggressive clinical course that renders prognostication and choice of treatment strategy difficult. Chemo-immunotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone (R-CHOP) is the current first-line trea...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Marchesi F,Regazzo G,Palombi F,Terrenato I,Sacconi A,Spagnuolo M,Donzelli S,Marino M,Ercolani C,Di Benedetto A,Blandino G,Ciliberto G,Mengarelli A,Rizzo MG

更新日期：2018-05-02 00:00:00

abstract：BACKGROUND:Dysregulation of transforming growth factor β (TGF-β) signaling and hypoxic microenvironment have respectively been reported to be involved in disease progression in malignancies of prostate. Emerging evidence indicates that downregulation of TGFBR2, a pivotal regulator of TGF-β signaling, may contribute to ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhou H,Wu G,Ma X,Xiao J,Yu G,Yang C,Xu N,Zhang B,Zhou J,Ye Z,Wang Z

更新日期：2018-04-27 00:00:00

abstract：BACKGROUND:Dying cells after irradiation could promote the repopulation of surviving cancer cells leading to tumor recurrence. We aim to define the role of dying cells in promoting pancreatic cancer cells metastasis following radiotherapy. METHODS:Using the transwell system as the in vitro co-culture model, a small nu...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Chen X,Zhang L,Jiang Y,Song L,Liu Y,Cheng F,Fan X,Cao X,Gong A,Wang D,Zhu H

更新日期：2018-04-03 00:00:00

abstract：BACKGROUND:Hippo/YAP pathway is known to be important for development, growth and organogenesis, and dysregulation of this pathway leads to tumor progression. We and others find that YAP is up-regulated in pancreatic ductal adenocarcinoma (PDAC) and associated with worse prognosis of patients. Activated pancreatic stel...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Jiang Z,Zhou C,Cheng L,Yan B,Chen K,Chen X,Zong L,Lei J,Duan W,Xu Q,Li X,Wang Z,Ma Q,Ma J

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:The preferential use of aerobic glycolysis by tumor cells lead to high accumulation of lactate in tumor microenvironment. Clinical evidence has linked elevated lactate concentration with cancer outcomes. However, the role and molecular mechanisms of lactate in cellular senescence and tumor progression remain...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Li X,Zhang Z,Zhang Y,Cao Y,Wei H,Wu Z

更新日期：2018-02-26 00:00:00

abstract：BACKGROUND:Extracellular matrix (ECM) is a mediator of tumor progression. However, whether the alterations of the intraperitoneal ECM prior to tumor establishment affects the malignant progression of ovarian cancer remains elusive. METHODS:Apolipoprotein (ApoE) knock-out mice was used to analyze the intraperitoneal EC...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lai H,Zhao X,Qin Y,Ding Y,Chen R,Li G,Labrie M,Ding Z,Zhou J,Hu J,Ma D,Fang Y,Gao Q

更新日期：2018-02-20 00:00:00

abstract：BACKGROUND:Oncogenic roles of epidermal growth factor receptor pathway substrate no.8 (EPS8) have been widely reported in various tumors, making targeting of EPS8 an appealing prospect. Here, we describe the role of EPS8 in acute myeloid leukemia (AML) and consider the potential of EPS8 as an anti-AML target. Nuclear l...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Chen Y,Xie X,Wu A,Wang L,Hu Y,Zhang H,Li Y

更新日期：2018-01-22 00:00:00

abstract：BACKGROUND:Novel therapies tailored to the molecular composition of esophageal squamous cell carcinoma (ESCC) are needed to improve patient survival. We investigated the regulatory network of long intergenic non-protein coding RNA, regulator of reprogramming (linc-ROR) and sex-determining region Y-box 9 (SOX9), and the...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wang L,Yu X,Zhang Z,Pang L,Xu J,Jiang J,Liang W,Chai Y,Hou J,Li F

更新日期：2017-12-13 00:00:00

abstract：BACKGROUND:Pancreatic cancer is a lethal disease in part because of its potential for aggressive invasion and metastasis. Lipoxin A4 (LXA4) is one of the metabolites that is derived from arachidonic acid and that is catalyzed by 15-lipoxygenase (15-LOX), and it has recently been reported to exhibit anti-cancer effects....

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zong L,Chen K,Jiang Z,Chen X,Sun L,Ma J,Zhou C,Xu Q,Duan W,Han L,Lei J,Li X,Ma Q,Wang Z

更新日期：2017-12-11 00:00:00

abstract：BACKGROUND:Pharmacology-based target identification has become a novel strategy leading to the discovery of novel pathological biomarkers. Ellagic acid (EA), a dietary polyphenol compound, exhibits potent anticancer activities; however, the underlying mechanisms remain unclear. The current study sought to determine the...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wang N,Wang Q,Tang H,Zhang F,Zheng Y,Wang S,Zhang J,Wang Z,Xie X

更新日期：2017-12-02 00:00:00